The reference site for Pefloxacin

Pefloxacin is a quinolone drug used to treat bacterial infections. Pefloxacin has not been approved for use in the United States.

WHAT IS Pefloxacin?

Pefloxacin is a medication belonging to the antibiotic group known as fluoroquinolones. They work by killing bacteria or preventing their growth.

This medicine is used for the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.

Pefloxacin is currently not available in the United States.

 

Brand Name(s): Pefbid; Pefocin; Pefran; Pelox
CAS nº: 70458-92-3
(pe flox a sin)

 

Product Info

The sections below will provide you with more specific information and guidelines related to pefloxacin and its correct use. Please read them carefully.

FDA Information

Pefloxacin is not currently available in the United States, and is yet to recieve FDA approval.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

This medicine is used for the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.

Pefloxacin is a medication belonging to the antibiotic group known as fluoroquinolones.

Mechanism of action:

The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

Other uses for this medicine

Pefloxacin has been increasingly used as a veterinary medicine to treat microbial infections.

Dosage and using this medicine

Pefloxacin comes as an orally-administered tablet or as an infusion.

Take pefloxacin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

DOSAGE

Oral: Adults – 400 mg bid 7 to 10 days taken along with food.

IV Infusion: Adults – 400mg in 100ml of 5% dextrose slow infusion over 1 hr bid.

What special precautions should I follow?

BEFORE TAKING PEFLOXACIN:

Tell your doctor if you have brain or spinal cord disease, including arterisclerosis in the brain or epilepsy or other seizures. You may not be able to take pefloxacin, or you may require a dosage adjustment or special monitoring during treatment.

Moreover, please inform your doctor if you are taking any of the following drugs: antacids; iron supplements; didanosine or sucralfate. You may not be able to take pefloxacin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with pefloxacin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment, or whilst breast-feeding a baby.

Additionally, pefloxacin is not to be used in children below 12 years.

Avoid prolonged exposure to sunlight. Pefloxacin may increase the sensitivity of the skin to sunlight, and a severe sunburn may result.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

Please do not take a double dose of this medication unless otherwise directed by your doctor.

What side effects can this medication cause?

Get emergency medical help if you have any of these signs of an allergic reaction:

hives
difficulty breathing
swelling of your face, lips, tongue, or throat

Possible side effects from pefloxacin use may include:

gastric pain
nausea
vomiting
allergic skin reactions
photosensitivity
muscular pain
headache

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing,  then please call the local emergency services on 911.

Please note that symptoms of a pefloxacin overdose may include seizures.

Product Images

PICTURES OF PEFLOXACIN PILLS

Below you will find images and specific information on the principal types of pefloxacin that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PEFLOXACIN
Strength(s): 400 MG
Imprint: PEFLOXACIN
Manufacturer: HEALTHY LIFE PHARMACEUTICALS

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